Cofactor gm2 activator protein, catalyzes the degradation of the ganglioside gm2, and other molecules containing terminal n-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of gm2 ganglioside in neurons and neurodegenerative disorders termed the gm2 gangliosidoses. Beta subunit gene mutations lead to sandhoff disease (gm2-gangliosidosis type ii). [3] contents 1 references 2 further reading 3 genewiki+ specific 3. 1 related snps and diseases 3. viagra cheapest online 2 related diseases references ↑ o'dowd bf, quan f, willard hf, lamhonwah am, korneluk rg, lowden ja, gravel ra, mahuran dj (apr 1985). "isolation of cdna clones coding for the beta subunit of human beta-hexosaminidase". get free trial viagra Proc natl acad sci u s a 82 (4): 1184–8. Doi:10. 1073/pnas. 82. 4. 1184. Pmc 397219. viagra vs viagra reviews Pmid 2579389.   ↑ korneluk rg, mahuran dj, neote k, klavins mh, o'dowd bf, tropak m, willard hf, anderson mj, lowden ja, gravel ra (jul 1986). "isolation of cdna clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on tay-sachs disease". J biol chem 261 (18): 8407–13. Pmid 3013851. buy viagra   ↑ 3. 0 3. 1 "entrez gene: hexb hexosaminidase b (beta polypeptide)". Viagra 5mg half life   further reading mahuran dj (1991). "the biochemistry of hexa and hexb gene mutations causing gm2 gangliosidosis. ". how hard is it to get a prescription for viagra Biochim. Biophys. Acta 1096 (2): 87–94. Pmid 1825792.   mahuran dj (1999). generic viagra trusted pharmacy "biochemical consequences of mutations causing the gm2 gangliosidoses. Superlara 100 viagra ". Biochim. Biophys. where can i buy viagra locally without a prescription Acta 1455 (2-3): 105–38. do catholic health insurance plans cover viagra Pmid 10571007.   gilbert f, kucherlapati r, creagan rp, et al. natural herbs to replace viagra (1975). "tay-sachs' and sandhoff's diseases: the assignment of genes for hexosaminidase a and b to individual human chromosomes. cheap viagra wholesale ". Proc. Natl. viagra vs viagra reviews Acad. Sci. U. S. A. 72 (1): 263–7. viagra for cheap Doi:10. 1073/pnas. 72. viagra cost versus viagra 1. 263. cheap viagra for sale Pmc 432284. Pmid 1054503.   mcinnes b, potier m, wakamatsu n, et al. (1992). "an unusual splicing mutation in the hexb gene is associated with dramatically different phenotypes in patients from different racial backgrounds. ". buy generic viagra without a prescription J. Clin. Invest. 90 (2): 306–14. Doi:10. much does once daily viagra cost viagra buy online AAK Marine Index